| Link | S.R. One, Limited | Conshohocken | Pennsylvania | NPS Pharmaceuticals, Theratech | | | Biotechnology Medical Devices |
| Link | Saints | San Francisco | California | Mainstream Data, Inc, Sandlot Corporation (formerly ZZ Soft) | | | Communications Information Services Electronics Software Medical Devices Research |
| Link | Sanderling Ventures | San Mateo | California | | 1 | $1,300,000 | Biotechnology Software Medical Devices |
| Link | Sandler Capital Management | New York | New York | | 1 | $6,010,000 | Communications Information Services Electronics Software |
| Link | Saturn Management | | | 3form, Inc. | 1 | | |
 | Scale Ventures | Foster City | | Omniture Inc | 1 | $23,270,000 | Biotechnology Content & Media Information Services Electronics Software Storage Security |
| Link | Sentry Investments | | | | | | |
| Link | Sequel Venture Partners | Boulder | | Avinti, Inc | 2 | $4,130,000 | Biotechnology Information Services Electronics Software Storage Medical Devices Security |
| Link | Sequoia Capital | Menlo Park | California | Ingenix, Inc. | | | Communications Content & Media Information Services Electronics Software Storage Security |
| Link | Shasta Ventures | Menlo Park | | Logoworks, Inc | 1 | $6,000,000 | Content & Media Information Services Software Services Security |
| Link | Shearson Lehman/American Express- | New York | New York | Campus Pipeline | 1 | $4,510,000 | |
| Link | Siemens Venture Capital GmbH (AKA: SVC) | Munich | | EmWare | 1 | $4,800,000 | Communications Electronics Healthcare Services Software Advanced Materials Energy |
| Link | Sightline Partners | Minneapolis | Minnesota | SmartTalk | | | Healthcare Services Medical Devices |
 | Silicon Valley Bank | Salt Lake City | | | | | Biotechnology Hardware Software Medical Devices |
| Link | Smart Technology Ventures | Los Angeles | California | Inari, Spontaneous Technology | 2 | $15,650,000 | Communications Electronics Software Storage Energy |
| Link | Sorenson Capital | Lehi | | DigitalBridge, Star Bridge Systems, Inc | 1 | $2,330,000 | Electronics |
| Link | Sorrento Associates | San Diego | | | | | Electronics Software |
| Link | SoundView Technology Group | Old Greenwich | Connecticut | SCO Group, Inc | | | |
| Link | Spectrum Equity Investors | Boston | Massachusetts | Ingenix, Inc., SmartTalk | 2 | $52,660,000 | Information Services Electronics |
| Link | Spire Capital | New York | | Certiport, Inc | 1 | | Services |
| Link | Spray Venture Partners | Newton | | Facet Solutions | 1 | $6,550,000 | Medical Devices |
| Link | Staenberg Venture Partners (FKA: Staenberg Private Capital) | Seattle | Washington | | 1 | $2,790,000 | Software Services |
| Link | Stalay Capital Partners | | | Avinti, Inc, BioMicro Systems, Inc | 2 | | |
| Link | StarVest Partners | New York | | Icrossing | 1 | $2,790,000 | Information Services Software Services Security |
| Link | Streamboat Ventures | Burback | | Move Networks | 1 | $17,130,000 | Content & Media Information Services Electronics Software Services |
| Link | Summit Partners | Boston | Massachusetts | | | | Communications Information Services Healthcare Services Software Services Scientific Equipment |
| Link | SunAmerica Ventures | Los Angeles | California | Spontaneous Technology | 1 | $4,500,000 | Biotechnology Communications Information Services Hardware Software |
| Link | SV Life Sciences | Boston | | AlloCure | 1 | | Biotechnology Healthcare Services Medical Devices Scientific Equipment Research |
| Link | Svoboda Capital Partners | Chicago | Illinois | | 1 | $2,790,000 | |
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