 | Symantec | SYMC
| $5,199,370,000 | 17,100 | 300 | | |
 | Sorenson Media | | $240,000,000 | | 1 | | |
 | StoresOnline, Inc | IIG
| $151,600,000 | 384 | 250 | | |
 | Sonic Innovations | SNCI
| $122,480,000 | 639 | | | |
 | SirsiDynix | | $120,000,000 | 100 | 100 | | |
 | Sento Corporation | | $50,000,000 | 250 | 250 | | |
| Link | SuperGen | SUPG
| $38,080,000 | 89 | 20 | | |
 | SkullCandy | | $35,700,000 | 30 | 30 | $500,000 | |
 | Spillman Technologies, Inc | | $29,800,000 | 171 | 171 | | |
 | SCO Group, Inc | SCOX
| $21,660,000 | 150 | 150 | | |
 | SHPI | SHPI
| $13,300,000 | 30 | 30 | | |
 | Software Technology Group | | $13,000,000 | 110 | 110 | | |
| Link | Solera Networks | | $12,500,000 | 20 | 20 | $3,900,000 | |
 | Studeo, Inc | | $12,500,000 | 40 | 40 | | |
 | Sire Technologies | | $7,400,000 | 60 | 50 | | |
| Link | Sewell Direct | | $6,400,000 | 30 | 30 | | |
| Link | Simplicity Group | | $4,318,780 | 60 | 60 | | |
 | Sorenson Genomics | | $4,000,000 | 50 | 50 | | |
| Link | Sorenson Medical | | $4,000,000 | 50 | 50 | | |
| Link | Sorenson BioScience, Inc. | | $3,500,000 | 50 | 50 | | |
| Link | Senforce Technologies, Inc | | $3,000,000 | 30 | 30 | | |
| Link | Setpoint Systems | | $3,000,000 | 0 | 0 | | |
| Link | SliceX | | $2,500,000 | 30 | 30 | $10,000,000 | |
| Link | SurgeWorks | | $2,500,000 | 30 | 30 | | |
| Link | ServerPlus, LLC. | | $2,300,000 | 52 | 52 | | |
| Link | ShopSite, Inc | | $2,000,000 | 20 | 20 | | |
 | S2, Inc. | | $1,000,000 | | 20 | $1,300,000 | |
| Link | Sequoia Media Group | | $1,000,000 | 25 | 25 | $8,800,000 | |
| Link | Sorenson Molecular Genealogy Foundation | | $1,000,000 | 30 | 30 | | |
| Link | Star Bridge Systems, Inc | | $1,000,000 | 20 | 20 | | |
| Link | System Technology Inc | | $750,000 | 10 | 10 | | |
| Link | Smile Reminder, Inc. | | $500,000 | 20 | 20 | $3,265,000 | |
| Link | S Square Technologies | | $500,000 | 0 | 5 | | |
| Link | S5 Wireless, Inc | | $500,000 | 40 | 40 | $12,950,000 | |
| Link | Salus Therapeutics, Inc. | | $500,000 | 1,200 | 1200 | $3,900,000 | |
| Link | SabiOso | | $200,000 | 25 | 25 | | |
| Link | SentrX Animal Care | | $100,000 | 0 | 0 | | |
 | Sapphire Group | | | | | | |
| Link | SE2 Labs | | | 0 | 0 | | |
| Link | Security Metrics | | | 25 | 25 | | |
| Link | Siebel Systems | | | 250 | 250 | | |
 | Siemens Medical Solutions | | | 125 | 125 | | |
| Link | Singleedge | | | 10 | 10 | | |
 | Smart Bomb Interactive | | | 50 | 50 | | |
| Link | Smile Reminder | | | 0 | 0 | | |
 | Softchoice | | | | | | |
| Link | Sorenson Communications | | | 250 | 250 | | |
 | Sorenson Companies | | | 504 | 250 | | |
| Link | Sorenson Laboratories | | | 0 | 0 | | |
| Link | SOS Technical | | | 0 | 0 | | |
 | Spring Communications | | | 0 | 0 | | |
 | Statera | | | 200 | | | |
| Link | Storyrock Electronic Publishing | | | 0 | 0 | | |
 | SunGard Availability Services | | | 750 | 150 | | |
 | Surrex Solutions Corporation | | | 75 | | | |
| Link | Sandlot Corporation (formerly ZZ Soft) | | | 44 | 50 | $2,380,000 | |
| Link | SilentWhistle, Inc. | | | 40 | 40 | $300,000 | |
| Link | Soronti Inc | | | 20 | 20 | $130,000 | |
| Link | Spreeride, Inc. | | | 20 | 20 | $3,500,000 | |
| Link | Sunrise Publishing Group | | | 0 | 0 | $350,000 | |
| Link | Strata | | | | | | |
 | Sendside Networks | | | 15 | 15 | | |
| Link | Spontaneous Technology | | | | | | |
| Link | SmartTalk | | | | | | |
 | Simplifile | | | | | | |
 | Sparxent | | | | | | |
| Link | | |